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Genotropin treats severe growth hormone deficiency in adults, which can start in adulthood or continue from childhood. If you were treated as a child, your growth hormone levels will be rechecked after you stop growing.

How Genotropin Works

Buy Genotropin online is an artificial growth hormone (somatropin) that mimics natural human growth hormone. It helps bones and muscles grow and supports the right development of fat and muscle tissues. It is made using recombinant DNA technology, not from human or animal tissues.

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When Not to Use Genotropin

Do not use Genotropin if:

• You are allergic to somatropin or any of the ingredients in Genotropin.
• if You have an active tumor, treatment must be completed before starting Genotropin.
• You are seriously ill, such as after major surgery or injury.
• Your growth plates have closed (you have stopped growing).

Pregnancy and Breastfeeding

Do not use Genotropin if you are pregnant or could become pregnant without contraception. Consult your doctor if you are breastfeeding.

Before Starting Genotropin

Talk to your doctor if:

• You are taking thyroid hormone replacement; your thyroid function will need close monitoring.
• If you have diabetes, genotypin may affect your insulin sensitivity.
• If you have severe headaches, vision problems, or nausea, your doctor may check for increased pressure in your skull.
• You have low cortisol levels; your doctor may need to adjust your steroid dosage.
• If you are taking estrogen therapy, your Genotropin dose may need adjustment.
• You had cancer as a child; there is a higher risk of developing tumours again.
• Age over 80; older adults may be more sensitive to Genotropin.
• Your doctor will assess the risks and benefits if you have other health issues.

For Children with Prader-Willi Syndrome

• The doctor will provide a diet plan to help manage weight during treatment.
• Your doctor will check for breathing issues or infections before starting treatment.
• If you show breathing problems during treatment, your doctor may refer you to a specialist.
• Your doctor will monitor for scoliosis during treatment.
• If you develop a lung infection, inform your doctor for appropriate treatment.

Others with Chronic Kidney Disease

• Your doctor will assess kidney function and growth for a year before starting Genotropin.
• Continue treatment for kidney issues during Genotropin therapy.
• Stop Genotropin if you have a kidney transplant.

Children Born Small or Underweight

• Your doctor will check blood sugar and insulin levels before and during treatment.

Taking Other Medications

Inform your doctor about any other medications, including over-the-counter drugs. Some medications can affect how well Genotropin works, including:

• Diabetes medications
• Thyroid hormones
• Corticosteroids
• Sex hormones (like estrogens)
• Ciclosporin (for transplant patients)
• Anticonvulsants (for epilepsy)

How to Use Genotropin

How Much to Use; Follow your doctor’s and pharmacist’s instructions carefully. These may differ from this leaflet. If you need help understanding the label, ask for help.

Recommended Dosage

Your dose is unique to you, determined by your size, the condition being treated, and how well the growth hormone works for you. Your doctor will calculate your dose in milligrams (mg) based on your weight in kilograms (kg) or your body surface area in square meters (m²). It’s important not to change your dose or schedule without consulting your doctor.

Growth hormone deficiency in children: 0.025-0.035 mg per kg of body weight per day or 0.7-1.0 mg per m2 of body surface area per day. Higher doses may be needed. Continue treatment until physical development is complete.

Turner syndrome: 0.045-0.050 mg per kg of body weight per day or 1.4 mg per m2 of body surface area per day.

Chronic kidney insufficiency: 0.045-0.050 mg per kg of body weight per day or 1.4 mg per m2 of body surface area per day. Higher doses may be needed if growth is too slow.

Prader-Willi syndrome: 0.035 mg per kg of body weight per day or 1.0 mg per m2 of body surface area per day. Do not exceed 2.7 mg daily. Stop treatment if growth nearly stops after puberty.

Children born smaller or lighter than expected: 0.035 mg per kg of body weight per day or 1.0 mg per m2 of body surface area per day. Continue until the final height is reached. Stop after the first year if there is no response or if the final height is reached.

Adults with growth hormone deficiency:
You were treated as a child; start with 0.2-0.5 mg daily.
If you start treatment as an adult, begin with 0.15–0.3 mg daily.
Your dose will be adjusted based on regular blood tests and your response. The daily dose usually does not exceed 1.0 mg. Women may need higher doses than men. It’s important to check your dosage every 6 months to ensure it’s still effective for you.
If you are over 60, start with 0.1-0.2 mg daily and increase slowly. Use the lowest effective dose, which usually does not exceed 0.5 mg daily.

When to Use It Use GENOTROPIN as directed by your doctor or pharmacist.

How Long to Use It Continue taking GENOTROPIN as long as your doctor recommends.

If You Forget to Use It
If you miss a dose, you must talk to your doctor or pharmacist about what to do. Inject the missed dose as soon as you remember. If it’s almost time for your next dose, skip the missed dose. Refrain from injecting double the amount. Regular communication with your healthcare team is key to successful treatment.

If You Use Too Much (Overdose)
If you take too much, contact your doctor or pharmacist right away. You may feel shaky, sweaty, drowsy, or faint, and your blood sugar may drop too low and rise too high.

While You Are Using It,  

Take your medicine exactly as your doctor instructed. Inform all your doctors, dentists, and pharmacists that you are using GENOTROPIN. If you become pregnant while taking this medication, tell your doctor right away. If you use GENOTROPIN for growth hormone deficiency after a tumour, have regular check-ups to monitor for tumour recurrence.

If you have diabetes, check your blood sugar levels closely during treatment and discuss any changes with your doctor to adjust your diabetes medication if needed. Inform your doctor if you experience hip pain or start limping during treatment.

If you have muscle pain near the injection site due to the preservative metacresol, switch to a GENOTROPIN product without it. Report any stomach pain during treatment, as it may indicate pancreas inflammation. For injection instructions, see Appendix 1.

Things You Must Not Do  

Do not stop taking the medicine unless your doctor advises you to. Avoid taking any new medication without consulting your doctor. Do not share GENOTROPIN with anyone else, even if they have similar symptoms.

Things to Be Careful Of  

When mixing GENOTROPIN, do not shake the solution; mix it gently to avoid damaging the hormone. No effects on driving or using machines have been observed.

Genotropin Side Effects  

GENOTROPIN can cause side effects, but not everyone experiences them. If you notice any side effects, contact your doctor or pharmacist immediately.

Very Common Side Effects

• joint pain  
• Water retention (puffy fingers or swollen ankles)  

Common Side Effects of Genotropin

• Joint pain  
• Temporary redness, itchiness, or pain at the injection site  
• Numbness or tingling  
• Pain or burning in hands or underarms (Carpal Tunnel Syndrome)  
  Stiffness in arms and legs  
  Muscle pain  

Uncommon Effects of Genotropin

• Leukemia (rare in growth hormone deficiency patients)  
• Increased pressure in the brain (causing headaches, vision problems, or vomiting)  
• Numbness or tingling  
• Rash  
• Itching  
• Raised itchy bumps on the skin  
• Muscle pain  
• Breast enlargement (gynecomastia)  
• Water retention (temporary)  
• Breast enlargement (gynecomastia)  

Not Known Side Effects (frequency not estimated): 

• Type 2 diabetes  
• Facial swelling  
• Decreased cortisol levels in the blood  
• Stiffness in arms and legs  
• Increased pressure in the brain (headaches, vision problems, vomiting)  
• Rash  
• Itching  
• Raised itchy bumps on the skin  
• Redness, itchiness, or pain at the injection site  

Antibodies may form against the injected growth hormone but usually do not affect its effectiveness. The skin around the injection site may become uneven or lumpy, but this can be avoided by changing injection sites.

A rare side effect of metacresol is muscle inflammation near the injection site. If your doctor confirms this, switch to a GENOTROPIN product without metacresol. There have been rare cases of sudden death in patients with Prader-Willi syndrome, but no link to GENOTROPIN has been found.

If you feel hip or knee pain during treatment, your doctor may check for slipped capital femoral epiphysis or Legg-Calve-Perthes disease. Other potential side effects include high blood sugar or low thyroid hormone levels, which your doctor can test for and treat if necessary.

Rarely, pancreatic inflammation has been reported. If any side effects become severe or if you notice any not listed, inform your doctor or pharmacist. You can report side effects directly to the National Centre for Adverse Drug Reaction Monitoring at npra.gov.my.

Storage and Disposal of GENOTROPIN  

Storage

Before mixing: Store in a refrigerator (2°C to 8°C) or at room temperature (below 25°C) for up to 1 month. Keep the pre-filled pen in its outer carton to protect it from light.  
After mixing: Store in a refrigerator (2°C to 8°C). Do not freeze. The mixed product can be stored for 4 weeks at 2°C to 8°C. Users are responsible for other storage conditions.

Disposal  

Dispose of any unused product or waste according to local regulations. Do not refill empty GoQuick pre-filled pens; discard them properly.

Product Description  
GENOTROPIN